Ontology highlight
ABSTRACT:
SUBMITTER: Lackey DE
PROVIDER: S-EPMC6791934 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Lackey Denise E DE Reis Felipe C G FCG Isaac Roi R Zapata Rizaldy C RC El Ouarrat Dalila D Lee Yun Sok YS Bandyopadhyay Gautam G Ofrecio Jachelle M JM Oh Da Young DY Osborn Olivia O
Scientific reports 20191014 1
Insulin resistance is a key feature of obesity and type 2 diabetes. PU.1 is a master transcription factor predominantly expressed in macrophages but after HFD feeding PU.1 expression is also significantly increased in adipocytes. We generated adipocyte specific PU.1 knockout mice using adiponectin cre to investigate the role of PU.1 in adipocyte biology, insulin and glucose homeostasis. In HFD-fed obese mice systemic glucose tolerance and insulin sensitivity were improved in PU.1 AKO mice and cl ...[more]