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OnlineFDR: an R package to control the false discovery rate for growing data repositories.

ABSTRACT: SUMMARY:In many areas of biological research, hypotheses are tested in a sequential manner, without having access to future P-values or even the number of hypotheses to be tested. A key setting where this online hypothesis testing occurs is in the context of publicly available data repositories, where the family of hypotheses to be tested is continually growing as new data is accumulated over time. Recently, Javanmard and Montanari proposed the first procedures that control the FDR for online hypothesis testing. We present an R package, onlineFDR, which implements these procedures and provides wrapper functions to apply them to a historic dataset or a growing data repository. AVAILABILITY AND IMPLEMENTATION:The R package is freely available through Bioconductor (http://www.bioconductor.org/packages/onlineFDR). SUPPLEMENTARY INFORMATION:Supplementary data are available at Bioinformatics online.

SUBMITTER: Robertson DS

PROVIDER: S-EPMC6792083 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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onlineFDR: an R package to control the false discovery rate for growing data repositories.

Robertson David S DS Wildenhain Jan J Javanmard Adel A Karp Natasha A NA

Bioinformatics (Oxford, England) 20191001 20

<h4>Summary</h4>In many areas of biological research, hypotheses are tested in a sequential manner, without having access to future P-values or even the number of hypotheses to be tested. A key setting where this online hypothesis testing occurs is in the context of publicly available data repositories, where the family of hypotheses to be tested is continually growing as new data is accumulated over time. Recently, Javanmard and Montanari proposed the first procedures that control the FDR for o ...[more]

PMID: 30873526

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