Ontology highlight
ABSTRACT:
SUBMITTER: R MM
PROVIDER: S-EPMC6792157 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
R Manjunatha M MM Shandil Radha R Panda Manoranjan M Sadler Claire C Ambady Anisha A Panduga Vijender V Kumar Naveen N Mahadevaswamy Jyothi J Sreenivasaiah M M Narayan Ashwini A Guptha Supreeth S Sharma Sreevalli S Sambandamurthy Vasan K VK Ramachandran Vasanthi V Mallya Meenakshi M Cooper Christopher C Mdluli Khisi K Butler Scott S Tommasi Ruben R Iyer Pravin S PS Narayanan Shridhar S Chatterji Monalisa M Shirude Pravin S PS
ACS medicinal chemistry letters 20190923 10
We report a novel benzimidazole (BI) based DprE1 inhibitor that resulted from scaffold morphing of a 1,4-azaindole series. The clinical progression of the 1,4-azaindole series from our previous work validates the potential of exploring newer chemical entities with antimycobacterial activity driven via a noncovalent inhibition of the decaprenylphosphoryl-β-d-ribose-2'-epimerase (DprE1). The representative compounds from the new scaffold reported in this study exhibited an improved solubility and ...[more]