Unknown

Dataset Information

0

Prognostic value of 18F-FDG brain PET as an early indicator of neurological outcomes in a rat model of post-cardiac arrest syndrome.


ABSTRACT: Predicting neurological outcomes in patients with post-cardiac arrest syndrome (PCAS) is crucial for identifying those who will benefit from intensive care. We evaluated the predictive value of 18F-FDG PET. PCAS was induced in Sprague Dawley rats. Baseline and post-3-hour images were acquired. Standardized uptake value (SUV) changes before and after PCAS induction (SUVdelta) and SUV ratios (SUVR) of regional SUV normalized to the whole brain SUV were obtained. The Morris water maze (MWM) test was performed after 2 weeks to evaluate neurological outcomes and rats were classified into two groups based on the result. Of 18 PCAS rats, 8 were classified into the good outcome group. The SUVdelta of forebrain regions were significantly decreased in good outcome group (p?delta of hindbrain regions were not significantly different according to outcomes. The SUVR of forebrain regions were significantly higher and the SUVR of hindbrain regions were significantly lower in good outcome group (p?

SUBMITTER: Kim D 

PROVIDER: S-EPMC6794298 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Prognostic value of <sup>18</sup>F-FDG brain PET as an early indicator of neurological outcomes in a rat model of post-cardiac arrest syndrome.

Kim Daehee D   Yoon Hai-Jeon HJ   Lee Woon Jeong WJ   Woo Seon Hee SH   Kim Bom Sahn BS  

Scientific reports 20191015 1


Predicting neurological outcomes in patients with post-cardiac arrest syndrome (PCAS) is crucial for identifying those who will benefit from intensive care. We evaluated the predictive value of 18F-FDG PET. PCAS was induced in Sprague Dawley rats. Baseline and post-3-hour images were acquired. Standardized uptake value (SUV) changes before and after PCAS induction (SUV<sub>delta</sub>) and SUV ratios (SUVR) of regional SUV normalized to the whole brain SUV were obtained. The Morris water maze (M  ...[more]

Similar Datasets

| S-EPMC7393436 | biostudies-literature
| S-EPMC8664828 | biostudies-literature
| S-EPMC6681694 | biostudies-literature
| S-EPMC7532239 | biostudies-literature
| S-EPMC7198373 | biostudies-literature
| S-EPMC10211471 | biostudies-literature
| S-EPMC10817325 | biostudies-literature
| S-EPMC8284720 | biostudies-literature
| S-EPMC10261398 | biostudies-literature
| S-EPMC8648682 | biostudies-literature