Targeting the Janus Kinase Family in Autoimmune Skin Diseases.
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ABSTRACT:
SUBMITTER: Howell MD
PROVIDER: S-EPMC6794457 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Targeting the Janus Kinase Family in Autoimmune Skin Diseases.
Howell Michael D MD Kuo Fiona I FI Smith Paul A PA
Frontiers in immunology 20191009
Autoimmune skin diseases are characterized by significant local and systemic inflammation that is largely mediated by the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway. Advanced understanding of this pathway has led to the development of targeted inhibitors of Janus kinases (JAKinibs). As a class, JAK inhibitors effectively treat a multitude of hematologic and inflammatory diseases. Growing evidence suggests that JAK inhibitors are efficacious in atopic derma ...[more]
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