Ontology highlight
ABSTRACT:
SUBMITTER: Breau M
PROVIDER: S-EPMC6795405 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Breau Marielle M Houssaini Amal A Lipskaia Larissa L Abid Shariq S Born Emmanuelle E Marcos Elisabeth E Czibik Gabor G Attwe Aya A Beaulieu Delphine D Palazzo Alberta A Flaman Jean-Michel JM Bourachot Brigitte B Collin Guillaume G Tran Van Nhieu Jeanne J Bernard David D Mechta-Grigoriou Fatima F Adnot Serge S
JCI insight 20191003 19
Oxidative stress is a major contributor to chronic lung diseases. Antioxidants such as N-acetylcysteine (NAC) are broadly viewed as protective molecules that prevent the mutagenic effects of reactive oxygen species. Antioxidants may, however, increase the risk of some forms of cancer and accelerate lung cancer progression in murine models. Here, we investigated chronic NAC treatment in aging mice displaying lung oxidative stress and cell senescence due to inactivation of the transcription factor ...[more]