Safety and efficacy of a modified XELOX adjuvant regimen for patients with operated stage III colon cancer: a Chinese single-center experience.
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ABSTRACT:
SUBMITTER: Peng J
PROVIDER: S-EPMC6796386 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
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Safety and efficacy of a modified XELOX adjuvant regimen for patients with operated stage III colon cancer: a Chinese single-center experience.
Peng Jianhong J Li Weihao W Zhang Rongxin R Lin Junzhong J Tang Jinghua J Wen Yongshan Y Lu Zhenhai Z Wu Xiaojun X Pan Zhizhong Z
Cancer communications (London, England) 20191016 1
<h4>Background</h4>A fixed 8-cycle oxaliplatin and capecitabine (XELOX) regimen has been the standard adjuvant therapy for patients with stage III colon cancer. However, completing the full-cycle of oxaliplatin is often associated with severe neurotoxicity. To spare patients from the toxic effects, without comprising the required efficacy, we evaluated the safety and efficacy of a modified XELOX (mXELOX) adjuvant chemotherapy regimen with 6 cycles of oxaliplatin and a full cycle of capecitabine. ...[more]
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