Unknown

Dataset Information

0

Peripheral leukocyte count and risk of bleeding in patients with non-valvular atrial fibrillation taking dabigatran: a real-world study.


ABSTRACT: BACKGROUND:The association between peripheral leukocyte count and bleeding events in nonvalvular atrial fibrillation (NVAF) patients treated with dabigatran remains unclear. This study aimed to explore the association between leukocyte count and bleeding events after excluding other confounders in NVAF patients taking dabigatran. METHODS:A total of 851 NVAF patients treated with dabigatran (110 mg bid) were recruited from 12 centers in China from February 2015 to December 2017. Follow-up was completed by May 2018. The exposure and outcome variables were leukocyte count measured at baseline and the number of bleeding events within the subsequent 6 months. Multivariate Cox proportional hazards models were constructed to analyze independent associations, and a Cox proportional hazards regression with cubic spline functions and smooth curve fitting (penalized spline method) was used to address nonlinearity between leukocyte count and bleeding. The inflection point was calculated using a recursive algorithm, and then a two-piecewise Cox proportional hazards model for both sides of the inflection point was constructed. RESULTS:During 6-month follow-up, 87 participants occurred bleeding events. For every 1?×?10/L increase in leukocyte count, the risk of bleeding increased by 11% (hazard ratio [HR]: 1.11, 95% confidence interval [CI]: 0.99-1.25). The smooth curve showed nonlinear relationship between leukocyte count and bleeding events. The inflection point of the leukocyte count was 6.75?×?10/L. For leukocyte counts < 6.75?×?10/L, the HR (95% CI) was 0.88 (0.69-1.13), and for leukocyte counts ? 6.75?×?10/L, the HR (95% CI) was 1.28 (1.09-1.51). CONCLUSION:This study found a J-shaped association between baseline leukocyte count and risk of bleeding in NVAF patients treated with dabigatran. CLINICAL TRIAL REGISTRATION:NCT02414035, https://clinicaltrials.gov.

SUBMITTER: Zhou W 

PROVIDER: S-EPMC6797159 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Peripheral leukocyte count and risk of bleeding in patients with non-valvular atrial fibrillation taking dabigatran: a real-world study.

Zhou Wei W   Wang Tao T   Zhu Ling-Juan LJ   Wen Ming-Hua MH   Hu Li-Hua LH   Huang Xiao X   You Chun-Jiao CJ   Li Ju-Xiang JX   Wu Yan-Qing YQ   Wu Qing-Hua QH   Bao Hui-Hui HH   Cheng Xiao-Shu XS  

Chinese medical journal 20190901 18


<h4>Background</h4>The association between peripheral leukocyte count and bleeding events in nonvalvular atrial fibrillation (NVAF) patients treated with dabigatran remains unclear. This study aimed to explore the association between leukocyte count and bleeding events after excluding other confounders in NVAF patients taking dabigatran.<h4>Methods</h4>A total of 851 NVAF patients treated with dabigatran (110 mg bid) were recruited from 12 centers in China from February 2015 to December 2017. Fo  ...[more]

Similar Datasets

| S-EPMC7189264 | biostudies-literature
| S-EPMC6608584 | biostudies-literature
| S-EPMC5129572 | biostudies-literature
| S-EPMC7288843 | biostudies-literature
| S-EPMC5411320 | biostudies-literature
| S-EPMC3356980 | biostudies-other
| S-EPMC7989114 | biostudies-literature
| S-EPMC5183492 | biostudies-other
| S-EPMC6709911 | biostudies-literature
| S-EPMC4828703 | biostudies-other