Dataset Information

Location-Scale Models in Demography: A Useful Re-parameterization of Mortality Models.

ABSTRACT: Several parametric mortality models have been proposed to describe the age pattern of mortality since Gompertz introduced his "law of mortality" almost two centuries ago. However, very few attempts have been made to reconcile most of these models within a single framework. In this article, we show that many mortality models used in the demographic and actuarial literature can be re-parameterized in terms of a general and flexible family of models, the family of location-scale (LS) models. These models are characterized by two parameters that have a direct demographic interpretation: the location and scale parameters, which capture the shifting and compression dynamics of mortality changes, respectively. Re-parameterizing a model in terms of the LS family has several advantages over its classic formulation. In addition to aiding parameter interpretability and comparability, the statistical estimation of the LS parameters is facilitated due to their significantly lower correlation. The latter, in turn, further improves parameter interpretability and reduces estimation bias. We show the advantages of the LS family over the typical parameterization of mortality models with two illustrations using the Human Mortality Database.

SUBMITTER: Basellini U

PROVIDER: S-EPMC6797696 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Location-Scale Models in Demography: A Useful Re-parameterization of Mortality Models.

Basellini Ugofilippo U Canudas-Romo Vladimir V Lenart Adam A

European journal of population = Revue europeenne de demographie 20181024 4

Several parametric mortality models have been proposed to describe the age pattern of mortality since Gompertz introduced his "law of mortality" almost two centuries ago. However, very few attempts have been made to reconcile most of these models within a single framework. In this article, we show that many mortality models used in the demographic and actuarial literature can be re-parameterized in terms of a general and flexible family of models, the family of location-scale (LS) models. These ...[more]

PMID: 31656456

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Project description:BACKGROUND: With the help of epigenome-wide association studies (EWAS), increasing knowledge on the role of epigenetic mechanisms such as DNA methylation in disease processes is obtained. In addition, EWAS aid the understanding of behavioral and environmental effects on DNA methylation. In terms of statistical analysis, specific challenges arise from the characteristics of methylation data. First, methylation ?-values represent proportions with skewed and heteroscedastic distributions. Thus, traditional modeling strategies assuming a normally distributed response might not be appropriate. Second, recent evidence suggests that not only mean differences but also variability in site-specific DNA methylation associates with diseases, including cancer. The purpose of this study was to compare different modeling strategies for methylation data in terms of model performance and performance of downstream hypothesis tests. Specifically, we used the generalized additive models for location, scale and shape (GAMLSS) framework to compare beta regression with Gaussian regression on raw, binary logit and arcsine square root transformed methylation data, with and without modeling a covariate effect on the scale parameter. RESULTS: Using simulated and real data from a large population-based study and an independent sample of cancer patients and healthy controls, we show that beta regression does not outperform competing strategies in terms of model performance. In addition, Gaussian models for location and scale showed an improved performance as compared to models for location only. The best performance was observed for the Gaussian model on binary logit transformed ?-values, referred to as M-values. Our results further suggest that models for location and scale are specifically sensitive towards violations of the distribution assumption and towards outliers in the methylation data. Therefore, a resampling procedure is proposed as a mode of inference and shown to diminish type I error rate in practically relevant settings. We apply the proposed method in an EWAS of BMI and age and reveal strong associations of age with methylation variability that are validated in an independent sample. CONCLUSIONS: Models for location and scale are promising tools for EWAS that may help to understand the influence of environmental factors and disease-related phenotypes on methylation variability and its role during disease development.

Dataset Information

Location-Scale Models in Demography: A Useful Re-parameterization of Mortality Models.

Publications

Location-Scale Models in Demography: A Useful Re-parameterization of Mortality Models.

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