Ontology highlight
ABSTRACT:
SUBMITTER: Roediger B
PROVIDER: S-EPMC6800251 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Roediger Ben B Lee Quintin Q Tikoo Shweta S Cobbin Joanna C A JCA Henderson James M JM Jormakka Mika M O'Rourke Matthew B MB Padula Matthew P MP Pinello Natalia N Henry Marisa M Wynne Maria M Santagostino Sara F SF Brayton Cory F CF Rasmussen Lorna L Lisowski Leszek L Tay Szun S SS Harris David C DC Bertram John F JF Dowling John P JP Bertolino Patrick P Lai Jack H JH Wu Wengen W Bachovchin William W WW Wong Justin J-L JJ Gorrell Mark D MD Shaban Babak B Holmes Edward C EC Jolly Christopher J CJ Monette Sébastien S Weninger Wolfgang W
Cell 20180913 2
The occurrence of a spontaneous nephropathy with intranuclear inclusions in laboratory mice has puzzled pathologists for over 4 decades, because its etiology remains elusive. The condition is more severe in immunodeficient animals, suggesting an infectious cause. Using metagenomics, we identify the causative agent as an atypical virus, termed "mouse kidney parvovirus" (MKPV), belonging to a divergent genus of Parvoviridae. MKPV was identified in animal facilities in Australia and North America, ...[more]