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An atypical parvovirus driving chronic tubulointerstitial nephropathy and kidney fibrosis

ABSTRACT: We have performed RNA sequencing on kidneys from inclusion body nephropathy-affected mice and compared the data to healthy, uninfected controls. Using a metagenomics approach, we report the identification of the disease causing agent as an atypical virus, mouse kidney parvovirus (MKPV), belonging to a divergent genus of the Parvoviridae. The RNA sequencing also enabled us to assess the host response to MKPV-infection.

ORGANISM(S): Mus musculus

PROVIDER: GSE117710 | GEO | 2018/07/27

REPOSITORIES: GEO

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An atypical parvovirus driving chronic tubulointerstitial nephropathy and kidney fibrosis

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