Ontology highlight
ABSTRACT:
SUBMITTER: Gao Y
PROVIDER: S-EPMC6800343 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Gao Yang Y Shuai Yichun Y Zhang Xuchen X Peng Yuwei Y Wang Lianzhang L He Jing J Zhong Yi Y Li Qian Q
Proceedings of the National Academy of Sciences of the United States of America 20190905 42
Different memory components are forgotten through distinct molecular mechanisms. In <i>Drosophila</i>, the activation of 2 Rho GTPases (Rac1 and Cdc42), respectively, underlies the forgetting of an early labile memory (anesthesia-sensitive memory, ASM) and a form of consolidated memory (anesthesia-resistant memory, ARM). Here, we dissected the molecular mechanisms that tie Rac1 and Cdc42 to the different types of memory forgetting. We found that 2 WASP family proteins, SCAR/WAVE and WASp, act do ...[more]