Ontology highlight
ABSTRACT:
SUBMITTER: Ma L
PROVIDER: S-EPMC6800571 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Ma Leyuan L Dichwalkar Tanmay T Chang Jason Y H JYH Cossette Benjamin B Garafola Daniel D Zhang Angela Q AQ Fichter Michael M Wang Chensu C Liang Simon S Silva Murillo M Kumari Sudha S Mehta Naveen K NK Abraham Wuhbet W Thai Nikki N Li Na N Wittrup K Dane KD Irvine Darrell J DJ
Science (New York, N.Y.) 20190701 6449
Chimeric antigen receptor-T cell (CAR-T) therapy has been effective in the treatment of hematologic malignancies, but it has shown limited efficacy against solid tumors. Here we demonstrate an approach to enhancing CAR-T function in solid tumors by directly vaccine-boosting donor cells through their chimeric receptor in vivo. We designed amphiphile CAR-T ligands (amph-ligands) that, upon injection, trafficked to lymph nodes and decorated the surfaces of antigen-presenting cells, thereby priming ...[more]