Ontology highlight
ABSTRACT:
SUBMITTER: Beyer HM
PROVIDER: S-EPMC6801210 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Beyer Hannes M HM Mikula Kornelia M KM Kudling Tatiana V TV Iwaï Hideo H
Extremophiles : life under extreme conditions 20190730 6
Self-splicing inteins are mobile genetic elements invading host genes via nested homing endonuclease (HEN) domains. All HEN domains residing within inteins are inserted at a highly conserved insertion site. A purifying selection mechanism directing the location of the HEN insertion site has not yet been identified. In this work, we solved the three-dimensional crystal structures of two inteins inserted in the cell division control protein 21 of the hyperthermophilic archaea Pyrococcus abyssi and ...[more]