Dataset Information

Evaluation of the Expression Level and Hormone Receptor Association of miR-126 in Breast Cancer.

ABSTRACT: Breast cancer is a major cause of cancer-related death in women worldwide. miRNAs are new players of breast tumorigenesis, used as diagnostic and prognostic biomarkers. Among various miRNAs, miR-126 has been proposed to have a tumor suppressive role in HER2 positive cancer. However, to have a better understanding of its role, further validation is required. The aim of this study was evaluating miR-126 expression level in breast cancer tissues and investigating its potential association with HER2, estrogen and progesterone receptors. miR-126 expression level was measured in 108 specimens including 78 malignant and 30 normal samples using RT-qPCR. The outcome was statistically analyzed. In silico studies were performed to find the potential mechanism of action, through which miR-126 imposes its function. Down-regulation of miR-126 was observed in tumor samples, as compared to the matched normal tissues. Down-regulation of miR-126 was also associated significantly with the absence of estrogen receptor in malignant samples. No association between miR-126 expression and HER2 status was observed. Our in silico analyses showed the possible role of Crk, PI3K and Ras proto-oncogenes in breast cancer tumorigenesis. miR-126 is significantly down-regulated in breast cancer tissues. Statistically, it showed no correlation with HER2 positivity. However, the association between lower miR-126 and estrogen receptor negativity was observed.

SUBMITTER: Rouigari M

PROVIDER: S-EPMC6801275 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Evaluation of the Expression Level and Hormone Receptor Association of miR-126 in Breast Cancer.

Rouigari Maedeh M Dehbashi Moein M Tabatabaeian Hossein H Ghaedi Kamran K Mohammadynejad Parisa P Azadeh Mansoureh M

Indian journal of clinical biochemistry : IJCB 20180616 4

Breast cancer is a major cause of cancer-related death in women worldwide. miRNAs are new players of breast tumorigenesis, used as diagnostic and prognostic biomarkers. Among various miRNAs, miR-126 has been proposed to have a tumor suppressive role in HER2 positive cancer. However, to have a better understanding of its role, further validation is required. The aim of this study was evaluating miR-126 expression level in breast cancer tissues and investigating its potential association with HER2 ...[more]

PMID: 31686732

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Dataset Information

Evaluation of the Expression Level and Hormone Receptor Association of miR-126 in Breast Cancer.

Publications

Evaluation of the Expression Level and Hormone Receptor Association of miR-126 in Breast Cancer.

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