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MiR-126 over-expression in highly metastatic LM2 breast cancer cells.

ABSTRACT: miR-126 were over-expressed using the miR-Vec system in highly metastatic LM2 cells. The LM2 cell line are described in detail in Minn et al. Nature 2005 This approach was used to conduct an unbiased search for specific miR-126 target genes in breast cancer cells. 4 Samples

ORGANISM(S): Homo sapiens

SUBMITTER: Nils Halberg

PROVIDER: E-GEOD-23905 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells.

Png Kim J KJ Halberg Nils N Yoshida Mitsukuni M Tavazoie Sohail F SF

Nature 20111214 7380

Metastatic progression of cancer is a complex and clinically daunting process. We previously identified a set of human microRNAs (miRNAs) that robustly suppress breast cancer metastasis to lung and bone and which display expression levels that predict human metastasis. Although these findings revealed miRNAs as suppressors of cell-autonomous metastatic phenotypes, the roles of non-coding RNAs in non-cell-autonomous cancer progression processes remain unknown. Here we reveal that endogenous miR-1 ...[more]

PMID: 22170610

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A microRNA regulon that mediates endothelial recruitment by metastatic human breast cancer cells.

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2011-12-16 | E-GEOD-23921 | biostudies-arrayexpress

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Tumorigenic-enriched (TE) and lung-metastatic (LM) derivatives and parental populations from the breast cancer MDA-MB-231 and CN34 cell lines

Project description:The LM2 derivative cell line is described in Minn et al. Nature 2005. The LM1a derivative cell line is described in Tavazoie et al. Nature 2008. Tumorigenic-enriched (TE) and lung-metastatic (LM) derivatives and their respective parental populations, from the breast cancer MDA-MB-231 and CN34 cell lines were transcriptomically compared in order to identify candidate regulators of breast cancer tumor re-initiation.

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Parental MeWo and highly metastatic LM2 human melanoma cell line derivatives with or without miR-199a or miR-1908

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Project description:the LM2 breast cancer cell line is an in vivo derived line from the MDA-MB-231 parental line. this LM2 line has been transduced either with a short hairpin control or miR-335 expression vector. Experiment Overall Design: the LM2 cell line is transduced either with a short hairpin control vector or miR-335 expression vector.

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