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MiR-126 over-expression in highly metastatic LM2 breast cancer cells.

ABSTRACT: miR-126 were over-expressed using the miR-Vec system in highly metastatic LM2 cells. The LM2 cell line are described in detail in Minn et al. Nature 2005 This approach was used to conduct an unbiased search for specific miR-126 target genes in breast cancer cells. 4 Samples

ORGANISM(S): Homo sapiens

SUBMITTER: Nils Halberg

PROVIDER: E-GEOD-23905 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells.

Png Kim J KJ Halberg Nils N Yoshida Mitsukuni M Tavazoie Sohail F SF

Nature 20111214 7380

Metastatic progression of cancer is a complex and clinically daunting process. We previously identified a set of human microRNAs (miRNAs) that robustly suppress breast cancer metastasis to lung and bone and which display expression levels that predict human metastasis. Although these findings revealed miRNAs as suppressors of cell-autonomous metastatic phenotypes, the roles of non-coding RNAs in non-cell-autonomous cancer progression processes remain unknown. Here we reveal that endogenous miR-1 ...[more]

PMID: 22170610

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A microRNA regulon that mediates endothelial recruitment by metastatic human breast cancer cells.

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2011-12-16 | E-GEOD-23921 | biostudies-arrayexpress

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Tumorigenic-enriched (TE) and lung-metastatic (LM) derivatives and parental populations from the breast cancer MDA-MB-231 and CN34 cell lines

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2015-04-02 | E-GEOD-52629 | biostudies-arrayexpress

Parental MeWo and highly metastatic LM2 human melanoma cell line derivatives with or without miR-199a or miR-1908

Project description:Human melanoma MeWo cells and their respective LM2 metastatic derivatives, generated through in vivo selection, were transcriptomically profiled in the context of miR-199a and miR-1908 gain- and loss-of-function in order to identify putative target genes for these miRNAs, MeWo cells and their respective LM2 metastatic derivatives in the context of miR-199a and miR-1908 gain- and loss-of-function

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Project description:the LM2 breast cancer cell line is an in vivo derived line from the MDA-MB-231 parental line. this LM2 line has been transduced either with a short hairpin control or miR-335 expression vector. Experiment Overall Design: the LM2 cell line is transduced either with a short hairpin control vector or miR-335 expression vector.

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