Ontology highlight
ABSTRACT:
SUBMITTER: Zheng W
PROVIDER: S-EPMC6801750 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Zheng Wenyi W Boada Roberto R He Rui R Xiao Tingting T Ye Fei F Simonelli Laura L Valiente Manuel M Zhao Ying Y Hassan Moustapha M
International journal of molecular sciences 20190924 19
Selenocompounds (SeCs) are well-known nutrients and promising candidates for cancer therapy; however, treatment efficacy is very heterogeneous and the mechanism of action is not fully understood. Several SeCs have been reported to have albumin-binding ability, which is an important factor in determining the treatment efficacy of drugs. In the present investigation, we hypothesized that extracellular albumin might orchestrate SeCs efficacy. Four SeCs representing distinct categories were selected ...[more]