Ontology highlight
ABSTRACT:
SUBMITTER: Laplagne C
PROVIDER: S-EPMC6801830 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20190923 19
The tumor bulk is composed of a highly heterogeneous population of cancer cells, as well as a large variety of resident and infiltrating host cells, extracellular matrix proteins, and secreted proteins, collectively known as the tumor microenvironment (TME). The TME is essential for driving tumor development by promoting cancer cell survival, migration, metastasis, chemoresistance, and the ability to evade the immune system responses. Therapeutically targeting tumor-associated macrophages (TAMs) ...[more]