Ontology highlight
ABSTRACT:
SUBMITTER: Pansy K
PROVIDER: S-EPMC6801866 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Pansy Katrin K Feichtinger Julia J Ehall Barbara B Uhl Barbara B Sedej Miriam M Roula David D Pursche Beata B Wolf Axel A Zoidl Manuel M Steinbauer Elisabeth E Gruber Verena V Greinix Hildegard T HT Prochazka Katharina T KT Thallinger Gerhard G GG Heinemann Akos A Beham-Schmid Christine C Neumeister Peter P Wrodnigg Tanja M TM Fechter Karoline K Deutsch Alexander Ja AJ
International journal of molecular sciences 20190924 19
In tumor cells of more than 20 different cancer types, the <i>CXCR4-CXCL12</i>-axis is involved in multiple key processes including proliferation, survival, migration, invasion, and metastasis. Since data on this axis in diffuse large B cell lymphoma (DLBCL) are inconsistent and limited, we comprehensively studied the <i>CXCR4-CXCL12</i>-axis in our DLBCL cohort as well as the effects of CXCR4 antagonists on lymphoma cell lines in vitro. In DLBCL, we observed a 140-fold higher <i>CXCR4</i> expre ...[more]