Ontology highlight
ABSTRACT:
SUBMITTER: Tsankov AM
PROVIDER: S-EPMC6803377 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Tsankov Alexander M AM Wadsworth Marc H MH Akopian Veronika V Charlton Jocelyn J Allon Samuel J SJ Arczewska Aleksandra A Mead Benjamin E BE Drake Riley S RS Smith Zachary D ZD Mikkelsen Tarjei S TS Shalek Alex K AK Meissner Alexander A
Development (Cambridge, England) 20190912 19
Maintenance of pluripotency and specification towards a new cell fate are both dependent on precise interactions between extrinsic signals and transcriptional and epigenetic regulators. Directed methylation of cytosines by the <i>de novo</i> methyltransferases DNMT3A and DNMT3B plays an important role in facilitating proper differentiation, whereas DNMT1 is essential for maintaining global methylation levels in all cell types. Here, we generated single-cell mRNA expression data from wild-type, D ...[more]