LCTL Is a Prognostic Biomarker and Correlates With Stromal and Immune Infiltration in Gliomas.
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ABSTRACT:
SUBMITTER: Su J
PROVIDER: S-EPMC6803540 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
<i>LCTL</i> Is a Prognostic Biomarker and Correlates With Stromal and Immune Infiltration in Gliomas.
Su Jun J Ma Qianquan Q Long Wenyong W Tang Hailin H Wu Changwu C Luo Mei M Wang Xiangyu X Xiao Kai K Li Yang Y Xiao Qun Q Zhang Chi C Li Haoyu H Liu Qing Q
Frontiers in oncology 20191015
Immune evasion in glioma strongly correlates with clinical outcomes; however, the molecular mechanisms driving the maintenance of immunosuppression remain largely unknown. Recently studies demonstrate that Klothos are aberrantly expressed in several cancers and are potential therapeutic targets in cancers. However, their roles are still unclear in glioma. Here, we show that <i>LCTL</i> is highly expressed in gliomas and that its expression is regulated by DNA methylation status at the promoter. ...[more]
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