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An Efficient Approach to Phosphorylated Isoindoline Fused with Triazoles via Zn-Catalyzed Cascade Cyclization of 2-Propynol Benzyl Azides and Diarylphosphine Oxides.

ABSTRACT: An efficient approach for the synthesis of phosphorylated isoindoline fused with triazoles via Zn(OTf)2-catalyzed cascade cyclization of easily prepared ortho-propynol benzyl azides and diarylphosphine oxides is developed. The transformation occurred smoothly in moderate to excellent yields and tolerated various propargylic alcohol substrates.

SUBMITTER: Yang T

PROVIDER: S-EPMC6803861 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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An Efficient Approach to Phosphorylated Isoindoline Fused with Triazoles via Zn-Catalyzed Cascade Cyclization of 2-Propynol Benzyl Azides and Diarylphosphine Oxides.

Yang Tao T Song Xian-Rong XR Yang Ruchun R Ding Haixin H Bai Jiang J Xiao Qiang Q

Molecules (Basel, Switzerland) 20190929 19

An efficient approach for the synthesis of phosphorylated isoindoline fused with triazoles via Zn(OTf)<sub>2</sub>-catalyzed cascade cyclization of easily prepared ortho-propynol benzyl azides and diarylphosphine oxides is developed. The transformation occurred smoothly in moderate to excellent yields and tolerated various propargylic alcohol substrates. ...[more]

PMID: 31569519

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