Ontology highlight
ABSTRACT:
SUBMITTER: Zalesak F
PROVIDER: S-EPMC6804241 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Zálešák František F Slouka Jan J Stýskala Jakub J
Molecules (Basel, Switzerland) 20191001 19
A simple general synthesis of 1-aryl-6-azaisocytosine-5-carbonitriles <b>4</b> is described. This method is based on coupling diazonium salts with cyanoacetylcyanamide <b>2</b> and then cyclization of the formed 2-arylhydrazono-2-cyanoacetylcyanamides <b>3</b>. The 6-azaisocytosines <b>4</b> were studied with respect to tautomeric equilibrium and the transformation of functional groups, and used in the synthesis of the condensed heterocyclic compounds: Purine isosteric imidazo[2,1-<i>c</i>]-[1,2 ...[more]