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Preparation of a Series of 5-Methyl-3-(substituted)-[1,2,4]triazines.

ABSTRACT: Procedures for the synthesis of thirty-six 5-methyl-3-(substituted)-[1,2,4]triazines have been described. These compounds were evaluated for antagonism at metabotropic glutamate receptor subtype 5. Two compounds, 5b and 3c, were determined to be low micromolar inhibitors of mGluR5.

SUBMITTER: Gichinga MG

PROVIDER: S-EPMC3138555 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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Preparation of a Series of 5-Methyl-3-(substituted)-[1,2,4]triazines.

Gichinga Moses G MG Olson Jeremy P JP Butala Elizabeth E Gilmour Brian P BP Navarro Hernán H HH Carroll F Ivy FI

Tetrahedron letters 20110601 26

Procedures for the synthesis of thirty-six 5-methyl-3-(substituted)-[1,2,4]triazines have been described. These compounds were evaluated for antagonism at metabotropic glutamate receptor subtype 5. Two compounds, 5b and 3c, were determined to be low micromolar inhibitors of mGluR5. ...[more]

PMID: 21779134

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