Ontology highlight
ABSTRACT:
SUBMITTER: Gichinga MG
PROVIDER: S-EPMC3138555 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Gichinga Moses G MG Olson Jeremy P JP Butala Elizabeth E Gilmour Brian P BP Navarro Hernán H HH Carroll F Ivy FI
Tetrahedron letters 20110601 26
Procedures for the synthesis of thirty-six 5-methyl-3-(substituted)-[1,2,4]triazines have been described. These compounds were evaluated for antagonism at metabotropic glutamate receptor subtype 5. Two compounds, 5b and 3c, were determined to be low micromolar inhibitors of mGluR5. ...[more]