Ontology highlight
ABSTRACT:
SUBMITTER: Igase M
PROVIDER: S-EPMC6804779 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Igase Masaya M Shibutani Shusaku S Kurogouchi Yosuke Y Fujiki Noriyuki N Hwang Chung Chew CC Coffey Matt M Noguchi Shunsuke S Nemoto Yuki Y Mizuno Takuya T
Molecular therapy oncolytics 20190828
Oncolytic virotherapy using reovirus is a promising new anti-cancer treatment with potential for use in humans and dogs. Because reovirus monotherapy shows limited efficacy in human and canine cancer patients, the clinical development of a combination therapy is necessary. To identify candidate components of such a combination, we screened a 285-compound drug library for those that enhanced reovirus cytotoxicity in a canine melanoma cell line. Here, we show that exposure to an inhibitor of the a ...[more]