Sequence variants with large effects on cardiac electrophysiology and disease.
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ABSTRACT:
SUBMITTER: Norland K
PROVIDER: S-EPMC6805929 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
Sequence variants with large effects on cardiac electrophysiology and disease.
Norland Kristjan K Sveinbjornsson Gardar G Thorolfsdottir Rosa B RB Davidsson Olafur B OB Tragante Vinicius V Rajamani Sridharan S Helgadottir Anna A Gretarsdottir Solveig S van Setten Jessica J Asselbergs Folkert W FW Sverrisson Jon Th JT Stephensen Sigurdur S SS Oskarsson Gylfi G Sigurdsson Emil L EL Andersen Karl K Danielsen Ragnar R Thorgeirsson Gudmundur G Thorsteinsdottir Unnur U Arnar David O DO Sulem Patrick P Holm Hilma H Gudbjartsson Daniel F DF Stefansson Kari K
Nature communications 20191022 1
Features of the QRS complex of the electrocardiogram, reflecting ventricular depolarisation, associate with various physiologic functions and several pathologic conditions. We test 32.5 million variants for association with ten measures of the QRS complex in 12 leads, using 405,732 electrocardiograms from 81,192 Icelanders. We identify 190 associations at 130 loci, the majority of which have not been reported before, including associations with 21 rare or low-frequency coding variants. Assessmen ...[more]
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