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Effectiveness of Immune Checkpoint Inhibitors in Transplant Recipients with Progressive Multifocal Leukoencephalopathy.

ABSTRACT: Antibodies against PD1 have been used to treat progressive multifocal leukoencephalopathy (PML), a rare brain disease caused by JC virus. We used these antibodies (nivolumab) to treat PML in 3 kidney transplant recipients. All died within 8 weeks of diagnosis. Hence, nivolumab did not improve PML outcome after solid organ transplantation.

SUBMITTER: Medrano C

PROVIDER: S-EPMC6810212 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Effectiveness of Immune Checkpoint Inhibitors in Transplant Recipients with Progressive Multifocal Leukoencephalopathy.

Medrano Chloé C Vergez François F Mengelle Catherine C Faguer Stanislas S Kamar Nassim N Del Bello Arnaud A

Emerging infectious diseases 20191101 11

Antibodies against PD1 have been used to treat progressive multifocal leukoencephalopathy (PML), a rare brain disease caused by JC virus. We used these antibodies (nivolumab) to treat PML in 3 kidney transplant recipients. All died within 8 weeks of diagnosis. Hence, nivolumab did not improve PML outcome after solid organ transplantation. ...[more]

PMID: 31625858

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