Atezolizumab Treatment for Progressive Multifocal Leukoencephalopathy.

ABSTRACT: Atezolizumab successfully reinvigorated JC virus immunity in a patient in Belgium with progressive multifocal leukoencephalopathy, as demonstrated by clinical, virologic, and radiologic response to treatment. However, the treatment also resulted in immune reconstitution inflammatory syndrome and life-threatening immune-related adverse events. These conditions were treated with corticosteroids, leading to treatment resistance.

SUBMITTER: Lambert N 

PROVIDER: S-EPMC8714204 | biostudies-literature |

REPOSITORIES: biostudies-literature