Principles for Integrative Structural Biology Studies.
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ABSTRACT:
SUBMITTER: Rout MP
PROVIDER: S-EPMC6810593 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Principles for Integrative Structural Biology Studies.
Rout Michael P MP Sali Andrej A
Cell 20190501 6
Integrative structure determination is a powerful approach to modeling the structures of biological systems based on data produced by multiple experimental and theoretical methods, with implications for our understanding of cellular biology and drug discovery. This Primer introduces the theory and methods of integrative approaches, emphasizing the kinds of data that can be effectively included in developing models and using the nuclear pore complex as an example to illustrate the practice and ch ...[more]
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