Ontology highlight
ABSTRACT:
SUBMITTER: Bae DW
PROVIDER: S-EPMC6811428 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Bae Da-Woon DW Jung Ye-Eun YE An Young Jun YJ Na Jung-Hyun JH Cha Sun-Shin SS
Antimicrobial agents and chemotherapy 20191022 11
ACC-1 is a plasmid-encoded class C β-lactamase identified in clinical isolates of <i>Klebsiella pneumoniae</i>, <i>Proteus mirabilis</i>, <i>Salmonella enterica</i>, and <i>Escherichia coli</i> ACC-1-producing bacteria are susceptible to cefoxitin, whereas they are resistant to oxyimino cephalosporins. Here, we depict crystal structures of apo ACC-1, adenylylated ACC-1, and acylated ACC-1 complexed with cefotaxime and cefoxitin. ACC-1 has noteworthy structural alterations in the R2 loop, the Ω l ...[more]