Ontology highlight
ABSTRACT:
SUBMITTER: Tanner L
PROVIDER: S-EPMC6811447 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Tanner Lloyd L Evans Joanna C JC Seldon Ronnett R Jordaan Audrey A Warner Digby F DF Haynes Richard K RK Parkinson Christopher J CJ Wiesner Lubbe L
Antimicrobial agents and chemotherapy 20191022 11
<i>Mycobacterium tuberculosis</i>, the causative agent of tuberculosis, remains a leading infectious killer globally, demanding the urgent development of faster-acting drugs with novel mechanisms of action. Riminophenazines such as clofazimine are clinically efficacious against both drug-susceptible and drug-resistant strains of <i>M. tuberculosis</i> We determined the <i>in vitro</i> anti-<i>M. tuberculosis</i> activities, absorption, distribution, metabolism, and excretion properties, and <i>i ...[more]