Fractionated irradiation of right thorax induces abscopal damage on testes leading to decline in fertility.
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ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC6811594 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
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Fractionated irradiation of right thorax induces abscopal damage on testes leading to decline in fertility.
Zhang Junling J Yao Dan D Song Yimeng Y Pan Yan Y Zhu Lin L Bai Yang Y Xu Yanwu Y Zhang Jianghong J Shao Chunlin C
Scientific reports 20191023 1
Radiation-induced abscopal effect (RIAE) may influence radiotherapy efficiency. However, it is unknown whether RIAE triggers abnormal genetic consequence. We present a novel evidence that, when mice were given fractionated irradiation on right thorax, the ultrastructure of blood-testis barrier was damaged in company with apoptosis induction in testes, and the sperm number and vitality were drastically decreased so that both the fertility and the survival of their offspring were reduced. Protein ...[more]
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