Ontology highlight
ABSTRACT:
SUBMITTER: Wonderlich ER
PROVIDER: S-EPMC6812841 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Wonderlich Elizabeth R ER Subramanian Krupa K Cox Bryan B Wiegand Ann A Lackman-Smith Carol C Bale Michael J MJ Stone Mars M Hoh Rebecca R Kearney Mary F MF Maldarelli Frank F Deeks Steven G SG Busch Michael P MP Ptak Roger G RG Kulpa Deanna A DA
PLoS pathogens 20191014 10
Studies have demonstrated that intensive ART alone is not capable of eradicating HIV-1, as the virus rebounds within a few weeks upon treatment interruption. Viral rebound may be induced from several cellular subsets; however, the majority of proviral DNA has been found in antigen experienced resting CD4+ T cells. To achieve a cure for HIV-1, eradication strategies depend upon both understanding mechanisms that drive HIV-1 persistence as well as sensitive assays to measure the frequency of infec ...[more]