Dataset Information

Fast Periodic Visual Stimulation EEG Reveals Reduced Neural Sensitivity to Fearful Faces in Children with Autism.

ABSTRACT: We objectively quantified the neural sensitivity of school-aged boys with and without autism spectrum disorder (ASD) to detect briefly presented fearful expressions by combining fast periodic visual stimulation with frequency-tagging electroencephalography. Images of neutral faces were presented at 6 Hz, periodically interleaved with fearful expressions at 1.2 Hz oddball rate. While both groups equally display the face inversion effect and mainly rely on information from the mouth to detect fearful expressions, boys with ASD generally show reduced neural responses to rapid changes in expression. At an individual level, fear discrimination responses predict clinical status with an 83% accuracy. This implicit and straightforward approach identifies subtle deficits that remain concealed in behavioral tasks, thereby opening new perspectives for clinical diagnosis.

SUBMITTER: Van der Donck S

PROVIDER: S-EPMC6813754 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Fast Periodic Visual Stimulation EEG Reveals Reduced Neural Sensitivity to Fearful Faces in Children with Autism.

Van der Donck Stephanie S Dzhelyova Milena M Vettori Sofie S Thielen Hella H Steyaert Jean J Rossion Bruno B Boets Bart B

Journal of autism and developmental disorders 20191101 11

We objectively quantified the neural sensitivity of school-aged boys with and without autism spectrum disorder (ASD) to detect briefly presented fearful expressions by combining fast periodic visual stimulation with frequency-tagging electroencephalography. Images of neutral faces were presented at 6 Hz, periodically interleaved with fearful expressions at 1.2 Hz oddball rate. While both groups equally display the face inversion effect and mainly rely on information from the mouth to detect fear ...[more]

PMID: 31468275

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Project description:The present study combined magnetoencephalography (MEG) recordings with fast periodic visual stimulation (FPVS) to investigate automatic neural responses to morphemes in developing and skilled readers. Native English-speaking children (N = 17, grade 5-6) and adults (N = 28) were presented with rapid streams of base stimuli (6 Hz) interleaved periodically with oddballs (i.e., every fifth item, oddball stimulation frequency: 1.2 Hz). In a manipulation-check condition, tapping into word recognition, oddballs featured familiar words (e.g., roll) embedded in a stream of consonant strings (e.g., ktlq). In the experimental conditions, the contrast between oddball and base stimuli was manipulated in order to probe selective stem and suffix identification in morphologically structured pseudowords (e.g., stem + suffix pseudowords such as softity embedded in nonstem + suffix pseudowords such as trumess). Neural responses at the oddball frequency and harmonics were analyzed at the sensor level using non-parametric cluster-based permutation tests. As expected, results in the manipulation-check condition revealed a word-selective response reflected by a predominantly left-lateralized cluster that emerged over temporal, parietal, and occipital sensors in both children and adults. However, across the experimental conditions, results yielded a differential pattern of oddball responses in developing and skilled readers. Children displayed a significant response that emerged in a mostly central occipital cluster for the condition tracking stem identification in the presence of suffixes (e.g., softity vs. trumess). In contrast, adult participants showed a significant response that emerged in a cluster located in central and left occipital sensors for the condition tracking suffix identification in the presence of stems (e.g., softity vs. stopust). The present results suggest that while the morpheme identification system in Grade 5-6 children is not yet adult-like, it is sufficiently mature to automatically analyze the morphemic structure of novel letter strings. These findings are discussed in the context of theoretical accounts of morphological processing across reading development.

Project description:Individuals with autism spectrum disorder (ASD) have difficulties with social communication and interaction. The social motivation hypothesis states that a reduced interest in social stimuli may partly underlie these difficulties. Thus far, however, it has been challenging to quantify individual differences in social orientation and interest, and to pinpoint the neural underpinnings of it. In this study, we tested the neural sensitivity for social versus non-social information in 21 boys with ASD (8-12 years old) and 21 typically developing (TD) control boys, matched for age and IQ, while children were engaged in an orthogonal task. We recorded electroencephalography (EEG) during fast periodic visual stimulation (FPVS) of social versus non-social stimuli to obtain an objective implicit neural measure of relative social bias. Streams of variable images of faces and houses were superimposed, and each stream of stimuli was tagged with a particular presentation rate (i.e., 6 and 7.5 Hz or vice versa). This frequency-tagging method allows disentangling the respective neural responses evoked by the different streams of stimuli. Moreover, by using superimposed stimuli, we controlled for possible effects of preferential looking, spatial attention, and disengagement. Based on four trials of 60 s, we observed a significant three-way interaction. In the control group, the frequency-tagged neural responses to faces were larger than those to houses, especially in lateral occipito-temporal channels, while the responses to houses were larger over medial occipital channels. In the ASD group, however, faces and houses did not elicit significantly different neural responses in any of the regions. Given the short recording time of the frequency-tagging paradigm with multiple simultaneous inputs and the robustness of the individual responses, the method could be used as a sensitive marker of social preference in a wide range of populations, including younger and challenging populations.

Dataset Information

Fast Periodic Visual Stimulation EEG Reveals Reduced Neural Sensitivity to Fearful Faces in Children with Autism.

Publications

Fast Periodic Visual Stimulation EEG Reveals Reduced Neural Sensitivity to Fearful Faces in Children with Autism.

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