Ontology highlight
ABSTRACT:
SUBMITTER: Dos Santos JV
PROVIDER: S-EPMC6814129 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Dos Santos Júnia Vieira JV Yu Renee Yin RY Terceros Andrea A Chen Brian Edwin BE
Molecular brain 20191024 1
Proper axonal branch growth and targeting are essential for establishing a hard-wired neural circuit. Here, we examined the role of Fibroblast Growth Factor Receptors (FGFRs) in axonal arbor development using loss of function and overexpression genetic analyses within single neurons. We used the invariant synaptic connectivity patterns of Drosophila mechanosensory neurons with their innate cleaning reflex responses as readouts for errors in synaptic targeting and circuit function. FGFR loss of f ...[more]