Ontology highlight
ABSTRACT:
SUBMITTER: Zamparo I
PROVIDER: S-EPMC6941231 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Zamparo Ilaria I Francia Simona S Franchi Sira Angela SA Redolfi Nelly N Costanzi Elisa E Kerstens Axelle A Fukutani Yosuke Y Battistutta Roberto R Polverino de Laureto Patrizia P Munck Sebastian S De Strooper Bart B Matsunami Hiroaki H Lodovichi Claudia C
Cell reports 20191201 13
In mammals, odorant receptors not only detect odors but also define the target in the olfactory bulb, where sensory neurons project to give rise to the sensory map. The odorant receptor is expressed at the cilia, where it binds odorants, and at the axon terminal. The mechanism of activation and function of the odorant receptor at the axon terminal is, however, still unknown. Here, we identify phosphatidylethanolamine-binding protein 1 as a putative ligand that activates the odorant receptor at t ...[more]