Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC6814173 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Liu Xia'nan X Lu Jinfeng J Liu Zhenshan Z Zhao Junjie J Sun Hongxiang H Wu Ningbo N Liu Hongzhi H Liu Weiwei W Hu Zhuqin Z Meng Guangxun G Shen Lei L Miller Aaron W AW Su Bing B Li Xiaoxia X Kang Zizhen Z
Journal of immunology (Baltimore, Md. : 1950) 20180119 5
Dysregulation of the immune barrier function of the intestinal epithelium can often result in dysbiosis. In this study we report a novel role of intestinal epithelial cell (IEC)-derived liver kinase B1 (LKB1) in suppressing colitogenic microbiota. IEC-specific deletion of LKB1 (LKB1<sup>ΔIEC</sup>) resulted in an increased susceptibility to dextran sodium sulfate (DSS)-induced colitis and a definitive shift in the composition of the microbial population in the mouse intestine. Importantly, trans ...[more]