Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh JC
PROVIDER: S-EPMC6814529 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Ghosh Jagadish C JC Seo Jae Ho JH Agarwal Ekta E Wang Yuan Y Kossenkov Andrew V AV Tang Hsin-Yao HY Speicher David W DW Altieri Dario C DC
Oncogene 20190812 43
Tumor mitochondria have heightened protein folding quality control, but the regulators of this process and how they impact cancer traits are not completely understood. Here we show that the ATP-directed mitochondrial protease, LonP1 is upregulated by stress conditions, including hypoxia, in tumor, but not normal cells. In mitochondria, LonP1 is phosphorylated by Akt on Ser173 and Ser181, enhancing its protease activity. Interference with this pathway induces accumulation of misfolded subunits of ...[more]