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The mitochondrial protease LonP1 promotes proteasome inhibitor resistance in multiple myeloma.

ABSTRACT: Purpose: We report the NGS-derived transcriptome profiling (paired-end RNA-seq) following proteasome inhibition in the multiple myeloma cell line MM.1S. Methods: MM.1S cells were treated for six hours with the synthetic proteasome inhibitor lactacystin or clinically-approved proteasome inhibitor bortezomib and RNA expression changes were quantified and compared to DMSO control-treated cells by RNA-sequencing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE166122 | GEO | 2021/03/06

REPOSITORIES: GEO

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Project description:Purpose: We report the NGS-derived transcriptome profiling (paired-end RNA-seq) following proteasome inhibition in the multiple myeloma cell line MM.1S. Methods: MM.1S cells were treated for six hours with the synthetic proteasome inhibitor lactacystin and RNA expression changes were quantified and compared to DMSO control-treated cells by RNA-sequencing.

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The mitochondrial protease LonP1 promotes proteasome inhibitor resistance in multiple myeloma.

Project description:The mitochondrial protease LonP1 promotes proteasome inhibitor resistance in multiple myeloma.

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Synthetic IDE inhibitors sensitize and reverse acquired resistance of multiple myeloma cells to proteasome inhibitors

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