Ontology highlight
ABSTRACT:
SUBMITTER: Yang Q
PROVIDER: S-EPMC6814691 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Yang Qi Q Guo Min M Zhou Yuan Y Hu Xue X Wang Yun Y Wu Chunchen C Yang Min M Pei Rongjuan R Chen Xinwen X Chen Jizheng J
Virologica Sinica 20190603 5
The phosphatidylserine-specific phospholipase A1 (PLA1A) is an essential host factor in hepatitis C virus (HCV) assembly. In this study, we mapped the E2, NS2 and NS5A involved in PLA1A interaction to their lumenal domains and membranous parts, through which they form oligomeric protein complexes to participate in HCV assembly. Multiple regions of PLA1A were involved in their interaction and complex formation. Furthermore, the results represented structures with PLA1A and E2 in closer proximity ...[more]