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Biological process activity transformation of single cell gene expression for cross-species alignment.

ABSTRACT: The maintenance and transition of cellular states are controlled by biological processes. Here we present a gene set-based transformation of single cell RNA-Seq data into biological process activities that provides a robust description of cellular states. Moreover, as these activities represent species-independent descriptors, they facilitate the alignment of single cell states across different organisms.

SUBMITTER: Ding H

PROVIDER: S-EPMC6814736 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Biological process activity transformation of single cell gene expression for cross-species alignment.

Ding Hongxu H Blair Andrew A Yang Ying Y Stuart Joshua M JM

Nature communications 20191025 1

The maintenance and transition of cellular states are controlled by biological processes. Here we present a gene set-based transformation of single cell RNA-Seq data into biological process activities that provides a robust description of cellular states. Moreover, as these activities represent species-independent descriptors, they facilitate the alignment of single cell states across different organisms. ...[more]

PMID: 31653878

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