Ontology highlight
ABSTRACT:
SUBMITTER: Leeman JE
PROVIDER: S-EPMC6815166 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Leeman Jonathan E JE Li Yi Y Bell Andrew A Hussain Suleman S SS Majumdar Rahul R Rong-Mullins Xiaoqing X Blecua Pedro P Damerla Rama R Narang Himanshi H Ravindran Pavithran T PT Lee Nancy Y NY Riaz Nadeem N Powell Simon N SN Higginson Daniel S DS
Proceedings of the National Academy of Sciences of the United States of America 20191007 43
Squamous cell carcinomas (SCCs) arising from aerodigestive or anogenital epithelium that are associated with the human papillomavirus (HPV) are far more readily cured with radiation therapy than HPV-negative SCCs. The mechanism behind this increased radiosensitivity has been proposed to be secondary to defects in DNA repair, although the specific repair pathways that are disrupted have not been elucidated. To gain insight into this important biomarker of radiosensitivity, we first examined genom ...[more]