Dataset Information

Cytotoxic Phenolic Compounds from Fruit Glandular Trichomes of Macaranga tanarius.

ABSTRACT: A new flavonoid, macatanarin D (1), together with five known stilbenes (2-6), was isolated from fruit glandular trichomes of Macaranga tanarius. Their structures were elucidated on the basis of spectroscopic methods and through comparison with data reported in the literature. All isolated compounds were evaluated for their cytotoxic activities against KB and MCF-7 cell lines. Compounds 3, 4, and 5 showed the strongest activities against both cell lines with IC₅₀ values in the range of 0.03-0.12??M, and compound 2 only showed a significant cytotoxicity against KB cell line (IC₅₀?=?0.26??M) and a moderate cytotoxicity against MCF-7 (IC₅₀?=?10.4??M). Compounds 1 and 6 showed weak cytotoxic activities against KB cell line with IC₅₀ values of 29.3 and 24.7??M, respectively.

SUBMITTER: Doan TMH

PROVIDER: S-EPMC6815561 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Cytotoxic Phenolic Compounds from Fruit Glandular Trichomes of Macaranga tanarius.

Doan Thi Mai Huong TMH Doan Thi Mai Huong TMH Nguyen Thuy Linh TL Trinh Thi Thanh Van TTV Vu Van Nam VN Phi Thi Dao TD Litaudon Marc M Roussi Fanny F Chau Van Minh VM Pham Van Cuong VC

Journal of analytical methods in chemistry 20191013

A new flavonoid, macatanarin D (1), together with five known stilbenes (2-6), was isolated from fruit glandular trichomes of Macaranga tanarius. Their structures were elucidated on the basis of spectroscopic methods and through comparison with data reported in the literature. All isolated compounds were evaluated for their cytotoxic activities against KB and MCF-7 cell lines. Compounds 3, 4, and 5 showed the strongest activities against both cell lines w ...[more]

PMID: 31737404

Similar Datasets

Project description:BackgroundOlive (Olea europaea L.) fruits contain numerous secondary metabolites, primarily phenolics, terpenes and sterols, some of which are particularly interesting for their nutraceutical properties. This study will attempt to provide further insight into the profile of olive phenolic compounds during fruit development and to identify the major genetic determinants of phenolic metabolism.ResultsThe concentration of the major phenolic compounds, such as oleuropein, demethyloleuropein, 3-4 DHPEA-EDA, ligstroside, tyrosol, hydroxytyrosol, verbascoside and lignans, were measured in the developing fruits of 12 olive cultivars. The content of these compounds varied significantly among the cultivars and decreased during fruit development and maturation, with some compounds showing specificity for certain cultivars. Thirty-five olive transcripts homologous to genes involved in the pathways of the main secondary metabolites were identified from the massive sequencing data of the olive fruit transcriptome or from cDNA-AFLP analysis. Their mRNA levels were determined using RT-qPCR analysis on fruits of high- and low-phenolic varieties (Coratina and Dolce d'Andria, respectively) during three different fruit developmental stages. A strong correlation was observed between phenolic compound concentrations and transcripts putatively involved in their biosynthesis, suggesting a transcriptional regulation of the corresponding pathways. OeDXS, OeGES, OeGE10H and OeADH, encoding putative 1-deoxy-D-xylulose-5-P synthase, geraniol synthase, geraniol 10-hydroxylase and arogenate dehydrogenase, respectively, were almost exclusively present at 45 days after flowering (DAF), suggesting that these compounds might play a key role in regulating secoiridoid accumulation during fruit development.ConclusionsMetabolic and transcriptional profiling led to the identification of some major players putatively involved in biosynthesis of secondary compounds in the olive tree. Our data represent the first step towards the functional characterisation of important genes for the determination of olive fruit quality.

Dataset Information

Cytotoxic Phenolic Compounds from Fruit Glandular Trichomes of Macaranga tanarius.

Publications

Cytotoxic Phenolic Compounds from Fruit Glandular Trichomes of <i>Macaranga tanarius</i>.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets