Impact of substance use disorder on gray matter volume in schizophrenia.
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ABSTRACT:
SUBMITTER: Quinn M
PROVIDER: S-EPMC6815746 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
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Impact of substance use disorder on gray matter volume in schizophrenia.
Quinn Margaret M McHugo Maureen M Armstrong Kristan K Woodward Neil N Blackford Jennifer J Heckers Stephan S
Psychiatry research. Neuroimaging 20180803
Substance use may confound the study of brain structure in schizophrenia. We used voxel-based morphometry (VBM) to examine whether differences in regional gray matter volumes exist between schizophrenia patients with (n = 92) and without (n = 66) clinically significant cannabis and/or alcohol use histories compared to 88 healthy control subjects. Relative to controls, patients with schizophrenia had reduced gray matter volume in the bilateral precentral gyrus, right medial frontal cortex, right ...[more]
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