Ontology highlight
ABSTRACT:
SUBMITTER: Fu L
PROVIDER: S-EPMC6815819 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Fu Lei L Peng Shifang S Wu Wanfeng W Ouyang Yi Y Tan Deming D Fu Xiaoyu X
Journal of cellular and molecular medicine 20190911 11
Mesenchymal stem cells (MSCs) have potential ability to differentiate into osteocytes in response to in vitro specific induction. However, the molecular basis underlying this biological process remains largely unclear. In this study, we identify lncRNA HOTAIRM1 as a critical regulator to promote osteogenesis of MSCs. Loss of HOTAIRM1 significantly inhibits the calcium deposition and alkaline phosphatase activity of MSCs. Mechanistically, we find that HOTAIRM1 positively modulates the activity of ...[more]