Ontology highlight
ABSTRACT:
SUBMITTER: Li F
PROVIDER: S-EPMC7554324 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Li Fang F Xu Yangfan Y Xu Xiaofang X Ge Shengfang S Zhang Feifei F Zhang He H Fan Xianqun X
Molecular therapy. Nucleic acids 20200916
In cancer cells, a gain of stemness may have profound implications for tumor initiation, aggressiveness, and clinical outcome. However, the molecular mechanisms underlying the self-renewal maintenance of cancer stem-like cells (CSCs) remain elusive. Here, based on analysis of transcriptome sequencing, we identified a long noncoding RNA (lncRNA) named HotairM1, which is weakly expressed in human colorectal carcinoma and uveal melanoma, and a much lower expression in corresponding CSCs. Our result ...[more]