Elevated Adenosine Deaminase Levels in the Cerebrospinal Fluid in Immune Checkpoint Inhibitor-induced Autoimmune Encephalitis.
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SUBMITTER: Fujiwara S
PROVIDER: S-EPMC6815906 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
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Elevated Adenosine Deaminase Levels in the Cerebrospinal Fluid in Immune Checkpoint Inhibitor-induced Autoimmune Encephalitis.
Fujiwara Satoru S Mimura Naoya N Yoshimura Hajime H Fujimoto Daichi D Ito Munehiro M Mori Ryobu R Ito Jiro J Tomii Keisuke K Kawamoto Michi M Kohara Nobuo N
Internal medicine (Tokyo, Japan) 20190627 19
Immune checkpoint inhibitors (ICIs) are promising drugs for various cancers. However, immune activation by ICIs can lead to immune-related adverse events (irAEs). Autoimmune encephalitis is a rare irAE, and its clinical features remain unknown. We herein report two patients with ICI-associated autoimmune encephalitis who, saliently, showed elevated adenosine deaminase (ADA) levels in the cerebrospinal fluid (CSF). This is the first report of increased ADA levels in the CSF of patients with ICI-i ...[more]
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