Ontology highlight
ABSTRACT:
SUBMITTER: Reiter JG
PROVIDER: S-EPMC6816333 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Reiter Johannes G JG Baretti Marina M Gerold Jeffrey M JM Makohon-Moore Alvin P AP Daud Adil A Iacobuzio-Donahue Christine A CA Azad Nilofer S NS Kinzler Kenneth W KW Nowak Martin A MA Vogelstein Bert B
Nature reviews. Cancer 20190827 11
Genetic intratumoural heterogeneity is a natural consequence of imperfect DNA replication. Any two randomly selected cells, whether normal or cancerous, are therefore genetically different. Here, we review the different forms of genetic heterogeneity in cancer and re-analyse the extent of genetic heterogeneity within seven types of untreated epithelial cancers, with particular regard to its clinical relevance. We find that the homogeneity of predicted functional mutations in driver genes is the ...[more]