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Intra-tumor genetic heterogeneity in breast cancers with heterogeneous HER2 gene amplification

ABSTRACT: We separately analyzed the HER2-negative and HER2-positive components of 12 HER2 heterogeneous breast cancers using gene copy number profiling and massively parallel sequencing, and identified potential driver genetic alterations restricted to the HER2-negative cells in each case. Our results indicate that even driver genetic alterations, such as HER2, can be heterogeneously distributed in a cancer, and that the HER2-negative components are likely driven by genetic alterations not present in the HER2-positive components, including BRF2 and DSN1 amplification.

ORGANISM(S): Homo sapiens

PROVIDER: GSE67908 | GEO | 2015/04/16

SECONDARY ACCESSION(S): PRJNA281183

REPOSITORIES: GEO

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