Ontology highlight
ABSTRACT:
SUBMITTER: Balasubramaniam M
PROVIDER: S-EPMC6817627 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Balasubramaniam Meenakshisundaram M Ayyadevara Srinivas S Ganne Akshatha A Kakraba Samuel S Penthala Narsimha Reddy NR Du Xiuxia X Crooks Peter A PA Griffin Sue T ST Shmookler Reis Robert J RJ
iScience 20190921
Diagnosis of neurodegenerative diseases hinges on "seed" proteins detected in disease-specific aggregates. These inclusions contain diverse constituents, adhering through aberrant interactions that our prior data indicate are nonrandom. To define preferential protein-protein contacts mediating aggregate coalescence, we created click-chemistry reagents that cross-link neighboring proteins within human, APP<sub>Sw</sub>-driven, neuroblastoma-cell aggregates. These reagents incorporate a biotinyl g ...[more]